EV-COMM:一种由细胞外囊泡介导的物种间和细胞间相互作用的数据库
Jingyu Chen1,2, Jing-Jing Lin3, Weiyi Wang3
1Xiamen Key Laboratory of Indoor Air and Health, Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.
Journal of extracellular vesicles
|April 21, 2024
概括
细胞外囊泡 (EVs) 调解物种内部和物种之间的通信. 我们开发了EV-COMM,这是一个新的数据库,详细介绍了EV介导的相互作用,捐赠者/接受者信息和功能性货物,以增强生物理解.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 生物间的相互作用对个人和社区的健康至关重要.
- 细胞外囊泡 (EVs) 是物种内部和物种间通信的关键媒介,运输分子载荷.
- 现有的数据库缺乏全面的捐赠者和接受者信息,用于EV介导的互动.
研究的目的:
- 开发一个全面的数据库 (EV-COMM) 用于EV介导的交互.
- 系统地编译和结构化有关电动汽车通信的数据,包括捐赠者/接收者的详细信息和功能性货物.
- 促进通过EVs介导的细胞-细胞和物种相互作用的理解.
主要方法:
- 编译EV介导的相互作用记录,结构化提供者和接受者信息 (细胞类型,组织/器官,物种).
- 包括关于EV隔离/识别方法,功能载荷 (如microRNA) 和生理/病理背景的数据.
- 开发了一个用于浏览,搜索,可视化和下载交互数据的Web界面.
主要成果:
- EV-COMM数据库包含1481个记录:971个细胞与细胞之间的相互作用和510个跨物种的相互作用.
- 相互作用跨越40个组织/器官,为EV通信提供了详细的见解.
- 数据库将microRNA货物与预测服务器连接起来,以进行潜在影响分析.
结论:
- EV-COMM是首个全面的数据库,专注于EV介导的捐赠者-接受者互动.
- 它是探索和验证跨细胞和物种EV介导通信的宝贵工具.
- 该数据库是免费访问的,并将不断更新.
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