相关实验视频

Updated: Jun 28, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

用基因印记检测检测的甲状腺诊断方式的逐步分析

Wanting Yang¹, Ming Yin², Jiehong Zhou¹

¹Department of Medical Ultrasound, West China Hospital, Sichuan University, Chengdu, China.

Chinese clinical oncology

|April 22, 2024

概括

标准的甲状腺结节评估每一步都会有所改善. 添加分子印记检测 (QCIGISH) 显著提高了手术前甲状腺癌诊断,特别是在困难的情况下.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
分子诊断学分子诊断

背景情况:

目前的甲状腺结节评估使用超声波,血清学和细针吸收 (FNA).
定量色素印记基因在位杂交 (QCIGISH) 的诊断价值,是一种分子测试,仍需得到充分证实.

研究的目的:

评估甲状腺结节恶性瘤风险的诊断方式的逐步贡献.
调查QCIGISH作为辅助分子测试的诊断意义.

主要方法:

通过超声波,血清学,FNA和QCIGISH评估了114个甲状腺结节.
建立了后勤回归模型来预测恶性瘤,评估每个诊断步骤的贡献.

主要成果:

超声波显示AUROC的值为0.79.
添加血清学和FNA改善了歧视 (AUROC 0.82和0.88).
QCIGISH进一步提高了诊断性能,达到0.95.9的AUROC.

结论:

标准的临床评估显著促进甲状腺结节风险分层.
QCIGISH提供了更准确的手术前评估,特别是在不确定的结节.

关键词:

不确定的甲状腺结节.表观遗传学是指表观遗传学.基因组印记是基因组的印记.分子测试分子测试试验.定量色素印记基因在现场杂交 (QCIGISH)

更多相关视频

An Ex vivo Culture System to Study Thyroid Development

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

相关概念视频

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...