调整阿里皮普拉的物理状态由中孔
Daniel Kramarczyk1, Justyna Knapik-Kowalczuk1, Joanna Klimontko1
1Faculty of Science and Technology, Institute of Physics, University of Silesia in Katowice, SMCEBI, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
Molecular pharmaceutics
|April 22, 2024
概括
半孔二氧化 (MS) 控制阿里皮普拉 (ARP) 的物理状态. 根据度,MS可以诱导或抑制再结晶,从而控制ARP的多态形式和物理稳定性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
背景情况:
- 控制活性药物成分 (API) 的物理状态对于药物产品的性能至关重要.
- 阿里皮普拉 (ARP) 是一种具有多种多态形式的抗精神病药物.
- 半孔二氧化 (MS) 是一种具有可调节性能的材料,用于药物输送应用.
研究的目的:
- 调查中性二氧化 (MS) 在控制阿里皮普拉 (ARP) 的物理状态和多态形式方面的作用.
- 确定MS度对ARP再结晶和物理稳定性的影响.
主要方法:
- 不同扫描热量计 (DSC) 分析热性质和相变.
- 宽带介电光谱 (BDS) 用于研究分子动力学和放松过程.
- 在无形ARP配方中MS含量的系统变化.
主要成果:
- 低MS含量 (<27重%) 促进ARP再结晶,有利于III多态形式.
- 中间MS含量 (27-65重量%) 抑制ARP再结晶,允许IV或X多态形式的形成.
- 高MS含量 (>65重量%) 产生无形ARP,具有增强的物理稳定性.
- 所有复合形式都表现出稳定的温度依赖放松时间.
结论:
- 半孔二氧化作为一种多功能辅助剂,用于控制阿里皮普拉的物理状态和多态性.
- 多发性硬化度是指导ARP向特定的多态形式或无形状态的关键因素.
- 这些发现提供了一个策略,以定制aripiprazole配方以达到所需的物理性质和稳定性.
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