在使用Endomethasone N vs SP根管密封剂后自发和口性内牙后疼痛:一个随机控制的临床试验
Yves Boucher1, Hugo Abrgall2, Vincent Bar2
1Department of Odontology, Piti�� Salp��tri��re Hospital, Paris, France; Department of Odontology, Paris Cit�� University, Paris, France; Orofacial Neurobiology Laboratory, Paris Cit�� University, Paris, France.
European endodontic journal
|April 22, 2024
概括
将皮质醇添加到根管密封剂 (RCS) 在内牙治疗 (ET) 后显著减少了内牙后疼痛 (PEP). 这项临床试验证明了内米他N RCS (EndoN) 与其无皮质素等效的优越性.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 疼痛管理 疼痛管理
- 材料科学 材料科学 材料科学
背景情况:
- 牙周内膜治疗后的疼痛 (PEP) 是牙周内膜治疗 (ET) 后的一种常见并发症.
- 根管密封剂 (RCS) 在ET的成功中起着至关重要的作用,并可能影响术后疼痛.
- 研究RCS中添加剂的止痛潜力对于改善患者的治疗结果至关重要.
研究的目的:
- 评估含有皮质素的根管密封剂 (Endomethasone N RCS - EndoN) 在减少内牙后疼痛方面的疗效,与无皮质素等效剂 (Endomethasone SP RCS - EndoSP) 相比.
- 评估EndoN对自发和痛,止痛剂摄入量,生活质量和ET后焦虑水平的影响.
主要方法:
- 一个多中心前性随机对照临床试验,涉及286名成年患者在牙或前中接受ET.
- 患者接受了EndoN或EndoSP,并在7天内使用视觉模拟量表 (VAS) 测量疼痛强度.
- 其次结果包括止痛药消费,生活质量和安全性评估.
主要成果:
- 与EndoSP (p<0.0001) 相比,EndoN显示了最大自发PEP (13.5对23.9) 和口PEP (12.3对24.0) 的统计学显著降低.
- 在所有评估时间内,在EndoN组中,性PEP始终较低.
- 在研究期间没有报告任何严重不良事件,这表明EndoN.N.的安全性概况有利.
结论:
- 含有皮质素的根管密封剂 (EndoN) 在缓解自发性和口性内牙后疼痛方面优于其无皮质素的对应物 (EndoSP).
- 这一发现支持使用皮质增强密封剂来改善内牙术后的疼痛管理.
- 该研究提供了高质量的证据 (A级方法),证明EndoN在减少PEP方面的临床益处.
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