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Updated: Jun 28, 2025

High-throughput Screening for Protein-based Inheritance in S. cerevisiae
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High-throughput Screening for Protein-based Inheritance in S. cerevisiae

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描述类蛋白质聚合:新兴的基于纳米孔的方法.

Nathan Meyer1,2, Joan Torrent2, Sébastien Balme1

  • 1Institut Européen des Membranes, UMR5635 University of Montpellier ENCSM CNRS, Place Eugène Bataillon, Cedex 5, Montpellier, 34095, France.

Small methods
|April 22, 2024
PubMed
概括

纳米孔技术提供了一种新的方法来检测和表征蛋白质聚合物,这对于理解神经退行性疾病,如阿尔茨海默氏症和帕金森症至关重要. 这种方法提供了对过渡性和异质物种的持续洞察,从而推进了诊断.

关键词:
粉样蛋白纤维是一种粉样蛋白纤维.这是一个纳米孔.类蛋白质的蛋白质寡合体.单分子技术的技术.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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