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Updated: Jun 28, 2025

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在脊髓伤后的微质中,ACOD1,而不是伊塔科纳酸,促进了p62介导的Nrf2的激活

Zhanyang Qian1, Mingjie Xia2, Tianyu Zhao1,3

  • 1Department of Orthopedics, Taizhou School of Clinical Medicine, Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, China.

Clinical and translational medicine
|April 22, 2024
PubMed
概括

甲酸脱碳酶1 (ACOD1) 通过减少神经炎症和氧化应激来保护脊髓损伤 (SCI). 一个新的ACOD1-p62-Nrf2反循环增强神经保护,与伊塔科纳特不同.

关键词:
Nrf2 没有任何问题.化脱碳酶 1 的作用.这就是 itaconate.神经炎症是一种神经炎症.在P62上,P62就是P62脊髓损伤导致的脊髓损伤

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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