一个基于纸质的双功能生物传感器,用于安全和用户友好的点护理尿液分析
Yujia Li1,2, Yingqi Kong1,2, Yubing Hu3
1Institute for Materials Discovery, University College London, London, WC1E 7JE, UK. bing.li@ucl.ac.uk.
Lab on a chip
|April 22, 2024
概括
一个新的纸质生物传感器提供了尿液pH和葡萄糖的安全,准确和同时分析. 这种医疗点技术简化了诊断,并最大限度地降低了临床环境中从业人员的健康风险.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 临床诊断 临床诊断 临床诊断 临床诊断
背景情况:
- 慢性病 (CKD) 的监测需要可靠的尿路生物标志物分析.
- 目前的方法往往是耗时的,医院依赖,或带来健康风险.
- 需要敏感,安全和用户友好的诊断工具.
研究的目的:
- 开发一种基于纸张的双重生物传感器,用于同时进行尿液pH和葡萄糖分析.
- 将生物传感器与临床尿样取样瓶集成,用于闭系统分析.
- 为前线临床环境提供安全准确的临床诊断工具.
主要方法:
- 在纸上制造基于氧化 (IrOx) 的电化学pH传感器.
- 使用葡萄糖氧化酶 (GOx),普鲁士蓝,金纳米粒子 (AuNPs),奇托桑和石墨复合材料开发葡萄糖传感器.
- 将传感器集成到密封的尿样取样瓶中,用于同时进行定量分析.
主要成果:
- pH传感器显示出超高灵敏度 (71.58 mV pH-1).
- 葡萄糖传感器实现了1.5μA mM-1的灵敏度.
- 临床验证显示,与商业方法的相关系数高 (pH为0.96,葡萄糖为0.98).
结论:
- 开发的双生物传感器提供了尿液生物标志物的快速,准确和安全分析.
- 密封的采样瓶设计可最大限度地降低健康风险,并简化程序.
- 这项技术在治疗慢性病时,对照料点诊断显著有前途.
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Instruct the patient to open their mouth and place...
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