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抗氧化剂补充剂对败血症患者短期死亡率的影响
Hui Pei1, Jie Qu1, Jian-Ming Chen1
1Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Heliyon
|April 22, 2024
概括
抗氧化剂疗法在减少败血症患者的短期死亡率方面显示出有前途. 尤其是亚斯科布酸,显著降低了住院和28天死亡率,但需要进一步证据.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 氧化压力研究研究 氧化压力研究
背景情况:
- 败血症的发展与过度的氧自由基产生和清除受损有关.
- 需要可靠的证据来证实抗氧化剂疗法在败血症中的有效性,特别是在短期死亡率方面.
- 了解氧化应激在败血症中的作用对于开发有效治疗方法至关重要.
研究的目的:
- 系统地审查和分析常见抗氧化剂治疗对成人败血症患者短期死亡率的影响.
- 评估各种抗氧化剂补充剂,包括单一和组合疗法,对败血症结局的影响.
- 提供基于证据的洞察力,了解抗氧化剂干预措施在败血症管理中的有用性.
主要方法:
- 在PubMed/Medline,Embase和Cochrane图书馆进行了系统的文献搜索,直到2023年11月,遵守PRISMA指南.
- 包括的研究集中在治疗抗氧化剂补充剂的成年败血症患者身上,如HAT,酸,胺,N-乙半氨酸和.
- 主要结局是短期死亡率,包括住院,28天,30天和重症监护室死亡率,并进行子组分析以解决异质性问题.
主要成果:
- 60项涉及130,986名败血症患者的研究被纳入了分析.
- 抗氧化剂治疗与短期死亡风险降低有关,包括在住院死亡率 (OR=0.81) 和28天死亡率 (OR=0.81) 的显著降低.
- 亚组分析强调,阿斯科布酸治疗显著降低了住院死亡率 (OR=0.66) 和28天死亡率 (OR=0.43). 对RCT的分析证实,抗氧化剂治疗,特别是甲酸,大大降低了短期死亡率.
结论:
- 随机对照试验的当前数据表明,抗氧化剂治疗,特别是甲酸,可能会改善败血症患者的短期死亡率.
- 虽然观察到改善结果的趋势,但证据需要进一步的强有力的证明.
- 需要进一步的研究来确定抗氧化剂治疗在败血症管理中的作用和最佳使用.
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