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Updated: Jun 28, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

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通过联合STING和TLR4刺激,协同的先天免疫激活和抗瘤免疫

Emily F Higgs, Thomas F Gajewski

    bioRxiv : the preprint server for biology
    |April 22, 2024
    PubMed
    概括

    将STING激动剂与TLR激动剂 (如LPS) 结合起来,通过协同激活NF-κB和IRF3通路来增强抗瘤免疫力. 这种协同方法显示了瘤控制的改善,为癌症治疗提供了新的治疗潜力.

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