健康人群的上呼吸道微生物群落是由利基和年龄决定的
Susan Zelasko1,2, Mary Hannah Swaney2,3, Shelby Sandstrom3
1Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
bioRxiv : the preprint server for biology
|April 22, 2024
概括
健康的婴儿和成人呼吸道微生物组在组成和功能上有显著差异. 鼻腔和口腔微生物群落的这些差异会影响整个生命周期的宿主健康.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 上呼吸道微生物组影响宿主健康和病原体殖民.
- 关于不同年龄组的呼吸道微生物群发育的比较研究有限.
研究的目的:
- 为了阐明健康的婴儿和成年人之间鼻腔和口腔微生物组组成和功能的差异.
- 为了比较不同年龄组的微生物组发育和功能.
主要方法:
- 鼻腔和口腔微生物组的枪支元基因组测序.
- 病原体抑制测定使用共生分离物.
- 微生物组组成,多样性和功能基因含量的比较分析.
主要成果:
- 显著的年龄和部位特定的微生物群贝塔多样性,α多样性和组成的变化.
- 口腔微生物组与鼻腔微生物组相比,表现出更高的抗菌素耐药性基因丰度.
- 婴儿口腔微生物组显示出更多的专门代谢物基因集群和更大的细菌抑制,而鼻腔分离物显示出更高的抗真菌活性.
结论:
- 与成年人相比,健康婴儿的鼻腔和口腔微生物群落存在显著差异.
- 这些发现增强了对呼吸道微生物群相互作用及其对宿主健康的影响的理解.
- 这项研究强调了微生物群落功能中与年龄相关的变化,这些变化与整个生命中的呼吸系统健康有关.
相关概念视频
Anatomy of Respiratory System I: Upper Respiratory Tract
1.4K
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
1.4K
Defense Mechanism Against Infection
6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Physical Assessment of the Respiratory Tract I: Health History
213
Physical assessment of the respiratory tract is critical to patient care. It allows healthcare professionals to identify and manage various respiratory conditions. The process involves a combination of subjective and objective data collection.
Subjective Data
Subjective data provides vital information about the patient's health history and symptoms. This data is typically collected through interviews in which patients describe their experiences, symptoms, and concerns.
Health history and...
Subjective Data
Subjective data provides vital information about the patient's health history and symptoms. This data is typically collected through interviews in which patients describe their experiences, symptoms, and concerns.
Health history and...
213
Anatomy of the Intestines
71.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.8K
What are Populations and Communities?
33.9K
Overview
33.9K


