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Updated: Jun 28, 2025

Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
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Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays

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阿尔法-同核素聚合物具有对酸酶的耐药性

S G Choi1, T Tittle1, D Garcia-Prada1

  • 1Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

bioRxiv : the preprint server for biology
|April 22, 2024
PubMed
概括

酸化α-synuclein (αsyn) 在血清129 (PSER129) 发生在健康的大脑中. 牛肠酸酶 (CIAP) 处理在同核蛋白病症研究中区分聚合PSER129和内源PSER129.

关键词:
帕金森病的发病因子翻译后的修改 翻译后的修改在死后的间隔间隔.蛋白质聚合蛋白质的聚合物

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Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

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Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation09:16

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相关概念视频

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
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Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
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