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相关概念视频

Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

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Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
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Phosphorylation01:02

Phosphorylation

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The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
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Recombinant &#945;- &#946;- and &#947;-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
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阿尔法-同核素聚合物具有对酸酶的耐药性.

S G Choi1, T Tittle1, D Garcia-Prada1

  • 1Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

bioRxiv : the preprint server for biology
|April 22, 2024
PubMed
概括
此摘要是机器生成的。

酸化α-synuclein (αsyn) 在血清129 (PSER129) 发生在健康的大脑中. 牛肠酸酶 (CIAP) 处理在同核蛋白病症研究中区分聚合PSER129和内源PSER129.

科学领域:

  • 神经科学是一个神经科学.
  • 生物化学 生物化学
关键词:
帕金森病的发病因子翻译后的修改 翻译后的修改在死后的间隔间隔.蛋白质聚合蛋白质的聚合物

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  • 病理学 病理学 病理学

    • 背景情况:

    • 阿尔法-同核素 (αsyn) 聚合是同核素病变的特征.
    • 血清129 (PSER129) 的酸化是病理性αsyn的标志物,但也发生在健康的神经元中.
    • 将内源PSER129与聚合PSER129区分开来,对于了解疾病机制至关重要.

    结论:

    • 阿尔法-同核素聚合物对酸酶降解有抗性.
    • CIAP预处理提高了在保存良好的样本中聚合PSER129检测的特异性.
    • 这种方法有助于了解PSER129在同核蛋白病变中的积累,并区分疾病标志物.