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时空大脑血流动力学是人类婴儿期出现边缘感应运动关联皮质梯度的基础

Minhui Ouyang^1,2, John A Detre^2,3, Jessica L Hyland¹

¹Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, United States.

bioRxiv : the preprint server for biology

|April 22, 2024

概括

婴儿大脑血流 (CBF) 地图显示出一个正在发展的皮质层次结构. 特定大脑区域的CBF增加与婴儿新兴的语言,运动和认知技能相关.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
医疗成像医学成像

背景情况:

婴儿大脑血流 (CBF) 对快速大脑发育至关重要,但其全脑动态仍然不清楚.
了解婴儿CBF模式对于了解大脑成熟和功能发育至关重要.

研究的目的:

以高分辨率绘制婴儿大脑血流 (CBF) 的地图.
揭示婴儿时期全脑CBF动态的组织原理.
将CBF模式与婴儿发育技能联系起来.

主要方法:

在100多名婴儿中利用了高分辨率的动脉旋转标记磁共振成像 (MRI).
生成了婴儿CBF详细地图,以可视化皮质活动.
分析了CBF变化与发展里程碑之间的关系.

主要成果:

确定了婴儿CBF地图中皮层层次的出现.
通过皮质区域观察到CBF增加的双相模式.
发现CBF增加的速度随着边缘感应运动协会皮质梯度而变化.
感觉运动皮层中增加的CBF与语言/运动技能以及前对对面皮层与认知技能有关.

结论:

这项研究通过CBF动态揭示了婴儿大脑发育的等级组织.
为婴儿大脑CBF提供了一个标准化的参考,有助于未来的研究.
提供了对皮层专业化和婴儿发育结果的生理基础的见解.

关键词:

标记为动脉脊柱的MRI.行为行为行为行为.大脑发育大脑发育的大脑发育大脑的血液流动.婴儿婴儿婴儿婴儿婴儿婴儿婴儿婴儿边缘-传感器-运动关联皮质梯度.神经发育的结果.

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