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简短报告:CAR Tregs在岛屿移植中调解相关抑制和传染性耐受性

Christine M Wardell^1,2, Vivian C W Fung^1,2, Eleanor Chen^1,2

¹BC Children's Hospital Research Institute, University of British Columbia; Vancouver, BC, Canada.

bioRxiv : the preprint server for biology

|April 22, 2024

概括

化学抗原受体Tregs (CAR Tregs) 在预防移植排斥和自身免疫方面表现有前途. 这项研究表明,CAR Tregs可以通过抑制T细胞对移植小岛和自我抗原的反应来控制糖尿病.

科学领域:

免疫学免疫学免疫学
细胞疗法细胞疗法
移植免疫学移植免疫学

背景情况:

调节性T细胞 (Tregs) 对免疫耐受性至关重要.
化学抗原受体 (CAR) 工程Tregs提供向免疫调节.
之前的研究证实CAR Tregs限制了免疫力,但它们对自身免疫力的影响是未知的.

研究的目的:

调查HLA-A2特异性CAR Tregs (A2-CAR Tregs) 是否可以控制由小岛自身反应性T细胞诱导的1型糖尿病.
在小岛移植模型中评估A2-CAR Tregs的治疗潜力.

主要方法:

利用HLA-A2阳性小岛移植的小鼠模型,将其移植到免疫缺陷的非肥胖糖尿病小鼠中.
对A2-CAR Tregs的收养转让进行了管理.
评估T细胞反应,糖尿病发病率和免疫耐受性.

主要成果:

A2-CAR Tregs显著降低了自动反应性T细胞的移植,增殖和细胞因子的产生.
移植的小岛和内源性胰腺受到了保护,防止了糖尿病的发病.
长期耐受性与新的Treg生成有关.

结论:

在移植模型中,A2-CAR Tregs有效控制小岛自身免疫,并预防糖尿病.
卡尔Tregs调解相关的抑制和传染性耐受性.
在小岛移植中,CAR Tregs具有治疗潜力,可以控制小岛移植和自身免疫.

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