分析发育中的大脑的纵向变化模式,使用功能和结构磁共振成像通过多模式融合进行分析
Rekha Saha1, Debbrata K Saha1, Zening Fu1
1Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University 55 Park Pl NE, Atlanta, GA 30303, USA.
bioRxiv : the preprint server for biology
|April 22, 2024
概括
功能性和结构性MRI的结合揭示了青少年大脑网络是如何变化的. 这项研究将功能变化模式与灰质体积联系起来,揭示了大脑发育中的性别特异性差异.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 医疗成像医学成像
背景情况:
- 青少年大脑发育涉及复杂的功能和结构变化.
- 功能性MRI (fMRI) 和结构性MRI (sMRI) 提供了对大脑动态的互补观点.
- 之前的研究已经确定了青少年大脑中的功能变化模式 (FCP).
研究的目的:
- 通过多式融合,将之前识别的FCP与大脑结构联系起来.
- 调查功能和结构性大脑变化的结合性特异性差异.
- 通过综合成像分析,增强对青少年大脑发育的理解.
主要方法:
- 在青少年大脑和认知发展 (ABCD) 数据集中应用了两种多式融合方法.
- 评估 voxelwise sMRI-FCP 合,以确定 FCP 的结构相关性.
- 采用多组合正规相关性分析 (mCCA) +联合独立组件分析 (jICA) 进行对称融合.
主要成果:
- 确定了FCP和灰色物质体积 (GMV) 变化之间的显著关联.
- 发现了与感官运动和认知控制网络的结构变化相关的特定FCP.
- 与男性相比,在女性中观察到更强的功能结构合.
结论:
- 结合fMRI和sMRI方法揭示了青少年大脑发育的复杂,性别特异的模式.
- 多模式融合增强了对动态大脑连接和结构的理解.
- 这些发现强调了综合分析对于全面了解神经成熟的重要性.
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