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用响应表面方法学优化瑞纳米脂质体的制备条件,并评估其稳定性

Xiaofeng Liu¹, Shuzhen Yu¹, Xiaoqin Lu¹

¹College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.

|April 22, 2024

概括

研究人员开发了素纳米脂质体 (QUE-NL-1),以改善素.

科学领域:

药理学和制药科学药理学和制药科学
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

奎尔是一种强效的黄醇,由于水溶性和稳定性差,其应用有限.
开发稳定和可溶性奎尔丁配方对于其治疗潜力至关重要.

研究的目的:

使用超声波薄膜分散方法制备和优化素纳米脂质体 (QUE-NL-1).
评估开发的纳米脂质体的稳定性,释放特征和安全性.

主要方法:

使用响应表面方法学优化素纳米脂质体制剂.
纳米脂质体的表征包括封装效率,粒子大小,泽塔潜力和PDI.
在模拟的胃肠道液体中评估奎尔素纳米脂质体稳定性和药物释放.
使用Caco-2细胞活力试验评估细胞毒性.

主要成果:

确定了最佳制备条件:蒸发温度为35°C,药物度为0.20 mg/mL,脂胆比为 4:1.
奎瑞纳米脂质体 (QUE-NL-1) 实现了63.73%的封装效率,134.11 nm粒子大小,和37.50的泽塔潜力 (PDI=0.24).
QUE-NL-1在模拟肠液中表现出良好的稳定性和持续释放.
QUE-NL-1具有较低的细胞毒性,Caco-2细胞存活率在0.4毫克/毫升的度下>90%.

结论:

建立了一种有效的方法来制备稳定,小型和安全的素纳米脂质体 (QUE-NL-1).
这些纳米脂质体显著增强素的稳定性,并使持续释放,扩大其应用潜力.
开发的奎尔塞丁纳米脂质体由于其有利的安全性,对制药应用具有前景.

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