开发纳米结构脂质载体载荷富含黄类丰富的生 officinale
Sharifah Sarah Shazwani1, Anita Marlina1,2, Misni Misran1
1Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
ACS omega
|April 22, 2024
概括
这项研究开发了一种使用纳米结构脂质载体 (NLC) 装载生 (Zingiber officinale) 黄的抗炎局部凝. 该NLC凝配方表现出增强的稳定性和均的颗粒分布,提供了一个有前途的局部药物递送系统.
科学领域:
- 药理学和制药学 药理学和制药学
- 自然产品化学 自然产品化学
- 材料科学 材料科学 材料科学
背景情况:
- 来自银杏花的黄酸具有抗氧化和抗炎性质.
- 纳米结构脂质载体 (NLCs) 提高了生物活性化合物的生物可用性和稳定性.
- 局部输送系统旨在提高局部疾病的治疗疗效.
研究的目的:
- 使用NLCs开发一种含有来自Zingiber officinale的黄类的抗炎局部凝.
- 为了评估含有黄的NLC配方的稳定性和特性.
- 评估这种NLC凝作为一种新型局部药物递送系统的潜力.
主要方法:
- 通过热同质化,使用酸,中链甘油三酸,异氨基氨酸,Tween 20和Span 20制备了NLC.
- 总黄酸含量被量化 (4.04 mg QUE/g 干取物).
- 进行了封装效率,颗粒大小,多分散度指数和形态分析.
主要成果:
- 最佳的含有黄的NLC配方实现了2%的生官提取物 (ZOE) 度,以获得最高的封装效率.
- 0.4%的ZOE度在28天后产生了稳定的NLC (302-344 nm粒子大小,0.14-0.23 PDI).
- 形态分析证实了稳定,均的NLC粒子分布.
结论:
- 与传统的凝相比,开发的带有ZOE的NLC凝具有优越的质量稳定性和固态特性.
- 这种NLC配方代表了用于局部应用的有希望的替代药物输送系统.
- 通过NLCs增强黄类药物的稳定性和生物可用性可能会导致改善抗炎治疗效果.
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