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美国人口中单细胞与淋巴细胞比率与前列腺癌之间的关联:基于人口的研究

Lanyu Wang¹, Xiaowan Li², Min Liu²

¹Department of Urology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, China.

Frontiers in cell and developmental biology

|April 22, 2024

概括

单细胞与淋巴细胞的比率 (MLR) 是前列腺癌 (PCa) 风险的潜在生物标志物. 较高的MLR水平表明美国成年人患PCa的风险较高.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物标志物生物标志物

背景情况:

炎症与前列腺癌 (PCa) 的发展有关.
单细胞与淋巴细胞比率 (MLR) 是一种非侵入性炎症生物标志物.
调查MLR与PCa的关联可以提供新的诊断见解.

研究的目的:

为了确定MLR和PCa之间的相关性.
为了比较MLR与PCa.其他炎症生物标志物的预测能力.

主要方法:

使用NHANES数据 (1999-2020年) 进行MLR和PCa分析.
采用加权多变量逻辑回归和通用添加模型.
进行了接收器操作特征 (ROC) 曲线分析,以评估诊断准确性.

主要成果:

在MLR和PCa (OR = 2.28) 之间观察到正相关性.
与NLR,SII,AISI,PLR和SIRI相比,MLR在预测PCa方面表现出更好的区分能力和准确性.
在MLR和年龄,BMI,高血压,糖尿病或吸烟状态之间没有发现显著的相互作用.

结论:

作为预测PCa风险的高级炎症生物标志物,MLR显示出希望.
较高的MLR,NLR,PLR,SII和AISI水平与美国成年人PCa风险增加有关.

关键词:

尼汉斯 (NHANES) 是一个名人.跨截面研究是跨截面研究.单细胞与淋巴细胞的比率.这是一项以人口为基础的研究.前列腺癌是前列腺癌.

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