维生素B12对大鼠中甲铁酸诱导的心脏毒性的作用
Nurhan Kuloğlu1, Derya Karabulut2, Emin Kaymak3
1Healthcare Services Department, Niğde Ömer Halisdemir University, Nigde, Turkey.
Iranian journal of basic medical sciences
|April 22, 2024
概括
维生素B12通过恢复分子标记物和减少心脏损伤,保护免受甲基酸心脏毒性影响. 建议在甲醇前后补充甲醇,以抵消叶酸枯竭.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 心血管研究研究心血管研究
背景情况:
- 甲甲酸 (MTX) 是一种具有抗炎和免疫抑制功能的化疗剂.
- MTX作为叶酸抗剂,可能导致心脏毒性.
- 了解MTX诱导心脏毒性的分子机制对于制定保护策略至关重要.
研究的目的:
- 研究MTX诱导心脏毒性背后的分子机制.
- 评估维生素B12对MTX心脏毒性的保护作用.
主要方法:
- 一项涉及32只大鼠的研究分为四组:对照组,维生素B12,MTX和MTX+维生素B12.
- 评估心脏组织标记物,包括缺氧诱导因子1α (HIF1-α),VEGFR-2,EPO,IL-6,催化酶 (CAT),超氧化物转化酶 (SOD) 和恶性甲 (MDA).
- 对血清生物标志物ANP和NT-proBNP的测量.
主要成果:
- 服用MTX导致HIF1-α和VEGFR-2表达增加,IL-6和EPO减少,CAT和SOD减少,MDA水平升高.
- 维生素B12补充剂显著逆转了这些MTX诱导的变化.
- 维生素B12还显著降低了由MTX引起的ANP和NT-proBNP水平的升高.
结论:
- 维生素B12在分子和生物化学水平上显示出对MTX诱导的心脏毒性的显著保护作用.
- 建议在MTX给药前后补充维生素B12,以减轻叶酸枯竭和相关的心脏损伤.
相关概念视频
01:46Electron Transport Chain: Complex I and II
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
01:30Vitamins
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
01:29Therapeutic Drug Monitoring: Affecting Factors
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
01:24Drug Toxicity: Risk factors
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...