超声波 eNose 对VOCs的感应,用于呼吸分析应用,使用基于eNose的分析仪
Johannes Glöckler1, Carsten Jaeschke1, Marta Padilla2
1Institute of Analytical and Bioanalytical Chemistry, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
ACS measurement science au
|April 22, 2024
概括
该iLovEnose电子鼻子准确地检测到模拟呼吸中的超追踪挥发性有机化合物 (VOC). 这项技术显示了未来使用呼气分析诊断疾病的前景.
科学领域:
- 分析化学 分析化学
- 生物医学工程 生物医学工程
- 传感器技术 传感器技术
背景情况:
- 呼出的气息中的挥发性有机化合物 (VOC) 是检测疾病的潜在生物标志物.
- 精确测量超追踪挥发性有机化合物具有挑战性,特别是在潮湿的条件下.
- 现有的呼吸分析方法可能需要复杂的样本处理.
研究的目的:
- 为了证明新型iLovEnose系统在模拟的人类呼吸中测量超追踪VOC的能力.
- 用一组金属氧化物 (MOX) 气体传感器来评估iLovEnose的性能.
- 评估系统对特定挥发性有机化合物的定量分析的可靠性.
主要方法:
- 使用了iLovEnose,这是一个气体传感器测试台,有三个温度控制的隔间.
- 配备了11个不同基础技术的MOX气体传感器.
- 在高湿度 (90%RH) 下使用随机测量分析了六个目标VOC在超低度 (0.0753 ppm) 下.
- 应用部分最小平方回归用于定量度估计.
主要成果:
- iLovEnose成功地区分了六种不同的VOC.
- 该系统提供了可靠的VOC度的定量测量.
- 在两周内,通过多次测量验证了性能.
结论:
- 该iLovEnose系统证明了检测和量化呼吸中的超微量VOC的可行性.
- 这项技术具有通过呼气分析进行非侵入性疾病诊断和监测的潜力.
- 进一步的开发可能会导致个性化医学的先进临床应用.
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