富含大麻的全谱提取物减少了在狗中麻醉诱导所需的普罗波福尔剂量 - 一项试点研究
João Lourenço Hasckel Gewehr1, Maria Laura Enzele1, Lucas Marlon Freiria2
1Veterinary Medicine, Federal University of Santa Catarina (UFSC), Curitibanos, Brazil.
Frontiers in veterinary science
|April 22, 2024
概括
植物性大麻素可能会降低在狗中诱导麻醉所需的propofol剂量. 这项研究发现,用6毫克/千克总体植物性大麻素减少了23%,这表明在兽医麻醉中潜在的辅助使用.
科学领域:
- 兽医麻醉学 兽医麻醉学
- 大麻素研究 研究 大麻素研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 大麻素具有治疗潜力,但它们对麻醉的影响尚不清楚.
- 人类休大麻使用者可能需要更高的麻醉剂量,与一些动物研究相反,表明大麻素激动剂对麻醉剂的强化.
- 这些差异可能是由于服用时间,剂量,植物性大麻素类型以及与内分泌系统的相互作用的变化.
研究的目的:
- 为了研究全谱,富含大麻素 (fsCBD) 提取物对狗的麻醉需求的影响.
- 为了评估植物大麻素作为辅助波诱导麻醉的潜力.
主要方法:
- 27只健康的雄犬被随机分为三个组:对照组 (橄油),2毫克/公斤fsCBD和6毫克/公斤fsCBD.
- 在普罗波福尔诱导前75分钟,通过粘膜进行治疗.
- 监测生理参数 (心率,呼吸率,血压,温度,镇静),并记录了用于诱导的propofol剂量.
主要成果:
- 与对照组相比,6 mg/kg fsCBD 组的诱导需要比对照组少23%的普罗波.
- fsCBD提取物没有在组内或组之间引起显著的镇静作用.
- 观察到心率和缩血压的统计学意义上的差异.
结论:
- 植物性大麻素可以作为兽医麻醉中的辅助选择,潜在地减少对普罗波的需求.
- 进一步的研究是有必要的,以优化剂量,管理,分子概况,安全性和药物相互作用的术后效果.
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