无症状高尿血和韩国成年人的高甘油三血-腰部表型之间的关系:一个跨部分研究
Ji-Eun Oh1, Sung Ryul Yu2, Jung-Yoon Yoo3
1Department of Biomedical Laboratory Science, Far East University, Eumseong, Republic of Korea.
概括
高甘油三和腰围的特征是高甘油三和腰围 (HTGW) 现型,与韩国成年人无症状高尿血症密切相关. 这种关联在糖尿病患者中尤为明显.
科学领域:
- 代谢健康 代谢健康
- 尿酸的新陈代谢 尿酸的新陈代谢
- 心脏代谢风险因素 心脏代谢风险因素
背景情况:
- 内脏脂肪的积累会对尿酸代谢产生负面影响.
- 超高甘油血症腰部 (HTGW) 现型意味着糖尿病和心脏代谢风险增加.
研究的目的:
- 调查HTGW表型与无症状高尿素血症之间的关联.
- 评估HTGW表型在韩国成年人中对高尿血的预测能力.
主要方法:
- 分析了一组23240名韩国成年人 (20-80岁) 的队列.
- HTGW表型是由血清甘油三酸盐 (TG) 和腰围 (WC) 的增加所定义的.
- 使用后勤回归和ROC曲线分析来评估关联和诊断能力.
主要成果:
- 在HTGW组中,高尿血的患病率是HTGW组的3.44倍,相比于正常TG正常腰部 (NTNW) 组.
- 高血压显著增加了男性 (HR 2.887) 和女性 (HR 7.341) 的高尿血风险,即使经过对混因素的调整.
- 在HTGW和糖尿病的组合中,出现无症状高尿血的概率最高 (2.55倍).
结论:
- 在韩国成年人中,HTGW表型与高尿血症显著相关,不论性别.
- 这种联系在患有糖尿病的个体中特别强烈.
- HTGW表型,可能与其他指标相结合,可以帮助识别高风险患高尿路血症的个体.
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