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Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
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微型无线供电和控制的植入物用于多站点刺激.

Iman Habibagahi1, Jaeeun Jang1, Aydin Babakhani1

  • 1Department of Electrical Engineering, University of California, Los Angeles, CA 90095 USA.

IEEE transactions on microwave theory and techniques
|April 22, 2024
PubMed
概括

这项研究介绍了一种微小的14毫米植入式设备,配备了用于双电压神经刺激的新型芯片系统 (SoC). 它可以为多达16个植入物进行同步治疗,证明了高效的无线电源和控制.

科学领域:

  • 生物医学工程 生物医学工程
  • 可植入的设备可以植入设备.
  • 神经调节是一种神经调节.

背景情况:

  • 微型植入式设备对于先进的神经调节疗法至关重要.
  • 高效的无线电源和控制是多种植入系统的关键挑战.

研究的目的:

  • 介绍一款具有集成芯片系统 (SoC) 的小型植入式装置.
  • 为了实现双电压刺激和多个植入物的无线可定位控制.
  • 用开发的系统来证明双边迷走神经刺激 (VNS) 的有效性.

主要方法:

  • 开发了一个直径为14毫米的植入物,以180纳米CMOS技术的新型SoC为套件.
  • 实现无线电源传输通过一个带感共振链接与单个Tx线圈.
  • 设计了SoC用于双电压 (1.8V, 3.3V) 刺激,具有100μs定时分辨率和低静电功率 (27μW).
  • 通过PCB定义的密码为同步疗法提供了集成的个人定位能力.

主要成果:

  • 在50mm时实现了高达80mm的无线操作,具有70°的角度错位容忍度.
  • SoC (0.75mm x 1.6mm) 显示了低静电消耗和精确的刺激控制.
  • 在猪模型中成功执行双边VNS,监测心率以验证有效性.
关键词:
CMOS 射频设计的设计在芯片上的射频系统 (SOC) 集成.生物效应和医疗应用.数据恢复数据的恢复.低功率RFIC设计的设计优化的优化优化优化.电力传输输电力传输的力量.

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结论:

  • 微型植入物和新 SoC 为多植入物,同步神经调节提供了一个强大的平台.
  • 该系统提供高效的无线电源,精确的控制,并在相关的体外模型中证明了有效性.
  • 这项技术对需要精确的神经刺激的先进个性化治疗干预有前途.