尿液生物标志物可以成为下尿路功能障碍差异诊断的有用工具
Wan-Ru Yu1,2, Yuan-Hong Jiang3, Jia-Fong Jhang3
1Department of Nursing, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Tzu chi medical journal
|April 22, 2024
概括
尿路生物标志物可以帮助非侵入性地区分各种下尿路功能障碍 (LUTD). 测量尿液中的特定蛋白质和氧化应激标志物显示出诊断诸如过度活跃的膀和间歇性囊炎等疾病的前景.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物化学 生物化学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 精确诊断下尿路功能障碍 (LUTD) 通常需要侵入性视频尿动力学研究.
- 开发针对LUTD的非侵入性查工具对于常规临床实践至关重要.
研究的目的:
- 审查最近关于使用尿路炎症蛋白和氧化应激生物标志物的临床研究,以识别男性和女性下尿路症状 (LUTS) 的特定LUTD.
主要方法:
- 对分析尿路生物标志物的临床研究进行了综述,其中包括化学因子 (CXCL-1,IL-8,MCP-1,RANTES,CXCL-10,eotaxin),细胞因子 (TNF-α,IL-2,IL-7,IL-6),氧化应激标志物 (8-OHdG,8-异) 和其他因素 (TAC,PGE2,BDNF).
- 生物标志物水平与特定的LUTD诊断的相关性,如detrusor过度活跃 (DO),间歇性囊炎/膀疼痛综合征 (IC/BPS),功能障碍排空 (DV) 和detrusor低活 (DU).
主要成果:
- 尿路CXCL-1和IL-8区分过度活跃的膀 (OAB) 和尿路感染.
- 8-OHdG和8-异质显示出识别混合DO和压力尿失禁的女性的潜力.
- 在DU中,TAC和PGE2与detrusor压力相关;在DU中,BDNF和PGE2表明detrusor功能恢复.
- 患有DV的女性中TNF-α和8-OHdG的水平较高;IL-2的水平较低.
- 在异形和神经性DO中,8-异质的含量升高.
- 在IC/BPS患者中,MCP-1,RANTES,CXCL-10,IL-7,eotaxin-1的含量较高.
- IL-8,CXCL-10,BDNF,IL-6,RANTES区分了亨纳的IC与非亨纳的IC.
- 欧素,MCP-1,TNF-α,8-OHdG,TAC在男性IC/BPS患者中较高;欧素和TNF-α联合有助于歧视.
结论:
- 测量尿路生物标志物集群可以作为诊断工具,在患有类似LUTS的患者中区分各种LUTD.
- 非侵入性尿路生物标志物分析提供了一个有希望的方法来补充或可能取代LUTD的侵入性诊断方法.
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