在接受视频辅助胸部手术的患者中,S-胺对术后恶心和吐的影响:一项随机对照试验
Yu Qi1,2,3, Meiyan Zhou1,2,3, Wenting Zheng1,2
1The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, People's Republic of China.
Drug design, development and therapy
|April 22, 2024
概括
在接受视频辅助胸腔镜手术 (VATS) 的患者中,外科期间的S-胺注入显著降低了术后恶心和吐 (PONV). 这种方法还降低了阿片类药物消费和改善了疼痛管理.
科学领域:
- 麻醉学 麻醉学
- 手术瘤学手术瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后恶心和吐 (PONV) 是手术后的一个常见并发症.
- 视频辅助胸腔镜手术 (VATS) 带腔切除术患者容易感染PONV.
- 缓解PONV的有效策略对于患者的康复至关重要.
研究的目的:
- 调查术前S-基他胺输注在减少PONV发病率方面的有效性.
- 为了评估S-胺对阿片类药物消费和疼痛管理在VATS叶切除术患者的影响.
主要方法:
- 一项前性,随机,双盲,受控的研究,涉及420名接受VATS叶切除术的患者.
- 患者接受了S-ketamine输液或盐水对照剂.
- 主要结局是PONV发病率;次要结局包括阿片类药物使用,血液动力学和疼痛评分.
主要成果:
- 与对照组 (30.5%) 相比,S-胺组的PONV发病率明显较低 (9.7%).
- 在S-氨酸组中,外科手术期间的阿片类药物消费 (雷米芬坦尼尔和苏芬坦尼尔) 显著减少.
- S-胺组经历了改善的血液动力稳定性和较低的术后疼痛评分 (VAS).
结论:
- 在外科手术期间注入S-胺是一种有效的方法,可以降低PONV在VATS叶切除术患者.
- 施用S-胺可降低阿片类药物需求并改善术后疼痛控制.
- 这项研究支持S-ketamine作为管理PONV和增强VATS叶切除术后恢复的宝贵辅助剂.
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