高脂蛋白:对风险评估和减轻风险的可行的策略
Gissette Reyes-Soffer1, Calvin Yeang2, Erin D Michos3
1Department of Medicine, Columbia University Irving Medical Center, NY, USA.
American journal of preventive cardiology
|April 22, 2024
概括
高脂蛋白 (Lp) 水平是动脉样硬化心血管疾病 (ASCVD) 的主要遗传风险. 现在建议进行全方位Lp (a) 查,以确定需要风险管理策略的人.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 脂质学 脂质学是指脂质学.
背景情况:
- 高脂蛋白[Lp[a]水平是动脉样硬化心血管疾病 (ASCVD) 和动脉狭窄症的重要遗传风险因素.
- 这种风险独立于低密度脂蛋白胆固醇 (LDL-C) 水平和生活方式的改变.
- 越来越多的证据支持Lp作为ASCVD的因果因素,需要重新评估心血管风险评估.
研究的目的:
- 审查测量Lp(a) 的临床价值,用于识别和管理心血管疾病 (CVD) 高风险患者.
- 提供可操作的指导,以减轻与Lp(a) 相关的心血管疾病风险.
- 解决对患有高Lp的个体实施初级和二级心血管疾病预防策略的差距.
主要方法:
- 对Lp(a) 在ASCVD中的作用的流行病学和遗传证据的审查.
- 对当前临床指导方针和共识声明的分析,建议普遍测量Lp.
- 在临床开发的第三阶段讨论新兴的阿波利波蛋白[a]降低疗法.
主要成果:
- 越来越多的证据证实了Lp (a) 是一种强大的,基因决定的ASCVD风险因素.
- 越来越多地建议使用通用Lp (a) 测量来增强心血管疾病风险分层.
- 第三阶段临床试验正在评估针对阿波的新疗法,以降低Lp水平.
结论:
- 现在临床上有必要对Lp (a) 进行普遍查,以确定患ASCVD高风险的个体.
- 由于缺乏既定的管理协议,为降低风险提供可操作的指导至关重要.
- 针对性疗法的开发为管理高Lp (a) 水平和降低心血管疾病风险提供了有希望的未来.
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