低血红蛋白水平和高的炎症性血液学比率与抑郁症和睡眠障碍相关
Tetsuya Akaishi1,2, Kumi Nakaya3,4, Naoki Nakaya3
1Department of Education and Support for Regional Medicine, Tohoku University Hospital, Sendai, JPN.
Cureus
|April 22, 2024
概括
低血红蛋白 (Hb) 水平和高的炎症性血液学比率,如中性粒细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR) 和血小板与淋巴细胞的比率 (PLR),与一般人群中抑郁状态和睡眠障碍的增加有关.
科学领域:
- 血液学 血液学 血液学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 血细胞计数,血红蛋白 (Hb) 水平,炎症性血液学比率和心理健康之间的联系仍然不太清楚.
- 现有研究尚未明确确定这些生理标志物与心理健康之间的联系.
研究的目的:
- 调查血细胞形状与精神健康状况,特别是抑郁状态和睡眠障碍之间的关联.
- 在分析这些关系时,要调整潜在的人口混因素.
主要方法:
- 一项回顾性,横截面的观察性研究使用了东北医疗大银行项目的6万多名志愿者的数据进行.
- 收集的数据包括人口统计信息,生活方式因素 (烟草使用),体重指数,以及心理困扰 (K6),失眠 (AIS) 和抑郁症 (CES-D) 的自我报告得分.
主要成果:
- 在血红蛋白 (Hb),血红素,中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 与K6,AIS和CES-D分数 (p<0.0001) 之间发现了显著的相关性.
- 在调整混因子后,低Hb水平与较高的CES-D得分有显著的关联 (aOR=0.965,p<0.0001).
- 炎症比率 (NLR,MLR,PLR) 也显示了与心理健康得分的显著调整的几率比率,男性的关联更明显.
结论:
- 在一般人群中,低血红蛋白水平和升高的炎性血液学比率 (NLR,MLR,PLR) 与抑郁状态和睡眠障碍有关.
- 这些发现表明,心理健康状况的血细胞概况中存在潜在的生物标志物,需要进一步调查.
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