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在妇科腹腔镜手术后预防术后恶心和吐的olanzapine:一个随机对照试验
Nanjin Chen1, Shuman Ji2, Junfei Liu3
1Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
Therapeutic advances in drug safety
|April 22, 2024
概括
口服 olanzapine 在妇科腹腔镜手术患者的术后恶心和吐显著降低. 这一发现为管理这种常见的手术并发症提供了新的预防方案.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 外科手术的结果
背景情况:
- 手术后恶心和吐 (PONV) 是妇科腹腔镜手术后的一个常见并发症.
- 有效的预防策略对于改善患者的康复和满意度至关重要.
研究的目的:
- 评估口服 olanzapine 在妇科腹腔镜手术后预防 PONV 的预防性疗效.
- 为了比较接受口服 olanzapine 和接受安慰剂的患者之间的 PONV 发病率.
主要方法:
- 一项随机对照试验,涉及241名接受妇科腹腔镜手术的成年女性患者.
- 患者在麻醉前一个小时接受了5毫克口服 olanzapine 或安慰剂.
- 所有参与者都接受了标准的抗emetic预防,其中包括德克萨米他和格拉尼塞特朗.
主要成果:
- 手术后24小时内恶心和/或吐的发生率在松平组 (8.3%) 与安慰剂组 (19.2%) (p=0.014) 相比,在松平组显著较低.
- 卡普兰-梅尔分析证实,在奥兰zapine组中,PONV的可能性较低.
- 多变量考克斯分析确定了 olanzapine 使用作为一个独立的保护因子对 PONV (HR: 0.35, p=0.012).
结论:
- 口服 olanzapine 在妇科腹腔镜手术后减少PONV风险方面表现出显著的预防性疗效.
- 在这种患者群体中,olanzapine可以被视为标准抗疗方案的宝贵补充,用于PONV预防.
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