年轻人的口腔癌:我们应该以不同的方式对待这些患者吗?
Mateusz Szewczyk1, Jakub Pazdrowski1, Paweł Golusiński2
1Department of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Center, Poznań, Poland.
Frontiers in oncology
|April 22, 2024
概括
口腔癌治疗结果没有与年龄相关的显著差异. 其他因素,而不是年龄,对于口腔癌患者的预后似乎更为关键.
科学领域:
- 在瘤学瘤学.
- 口腔医学是指口腔医学.
- 流行病学 流行病学
背景情况:
- 患者年龄对口腔癌治疗有效性的影响尚不清楚.
- 现有的研究还没有明确定义年轻人 (45岁以下) 口腔癌的患病率.
研究的目的:
- 调查45岁以下成年人口腔癌的患病率.
- 为了比较不同年龄组口腔癌患者的治疗结果.
主要方法:
- 在2010年至2021年期间接受治疗的284名口腔癌患者的回顾性分析.
- 主要分析:根据年龄分层的队列 (<45岁与≥45岁).
- 二次分析:1:1匹配对分析年轻患者 (45岁以下) 和老年患者 (55-70) 的性别和阶段.
主要成果:
- 主要分析显示,年龄组之间的疾病阶段或治疗结果没有显著差异.
- 老年患者表现出更高的并发病患病率,并且在匹配对分析中更可能是吸烟者.
- 年轻患者的血小板与淋巴细胞比率 (PLR) 和中性粒细胞与淋巴细胞比率 (NLR) 的平均值显著更高.
结论:
- 年龄不是口腔癌阶段或治疗结果的重要决定因素.
- 年龄以外的因素,如并发症和吸烟状况,可能在患者预后中发挥更为关键的作用.
- 需要进一步的研究来确定其他影响口腔癌治疗成功的关键变量.
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