胃食道逆流症和睡眠问题之间的双向相关性:系统性审查和元分析
Xiaolong Tan1, Shasha Wang2, Fengjie Wu1
1Department of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, China.
PeerJ
|April 22, 2024
概括
这项研究发现,失眠和睡眠时间短等睡眠问题显著增加了胃食道逆流症 (GERD) 的风险. GERD还增加了睡眠质量差的风险,证实了双向联系.
科学领域:
- 胃肠道学和睡眠医学
背景情况:
- 胃食道逆流性疾病 (GERD) 和睡眠问题是常见的疾病.
- 无论是GERD还是睡眠问题都与精神疾病有关,这表明存在重叠.
- 睡眠问题与GERD之间的关联需要进一步研究.
研究的目的:
- 进行一项元分析,探索睡眠问题与GERD之间的关联.
- 量化与各种睡眠障碍相关的GERD风险.
- 检查GERD对睡眠质量和持续时间的影响.
主要方法:
- 在PubMed,Cochrane图书馆,Embase和Web of Science进行了全面的文献搜索,直到2023年8月.
- 分析利用基于异质性的固定效应或随机效应模型 (I2).
- 出版偏差是使用漏斗图和埃格尔测试来评估的.
主要成果:
- 对22项研究的分析显示,失眠,睡眠障碍和睡眠时间短显地增加了GERD风险 (ORs从1.98到2.66).
- GERD与睡眠质量差 (OR = 1.47),睡眠障碍 (OR = 1.47) 和睡眠时间短 (OR = 1.17) 的风险增加有关.
- 在几个分析中观察到显著的异质性 (I2 > 50%).
结论:
- 在GERD和四种类型的睡眠问题之间存在双向关系.
- 这些发现为开发GERD和睡眠障碍综合治疗方法提供了基础.
- 进一步的研究可能会阐明这种双向关联背后的机制.
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