在COVID-19之后儿童的咳症状:单中心回顾性研究
Ling Liu1, Lu Zhang1, Pengxiang Zhou2,3
1Department of Pediatrics, Peking University Third Hospital, Beijing, China.
Frontiers in pediatrics
|April 22, 2024
概括
患有过敏疾病的儿童在COVID-19感染后经历了长期和更严重的咳. 过敏状况是儿童患者COVID后咳持续时间和强度的一个关键因素.
科学领域:
- 儿科呼吸系统医学 儿科呼吸系统医学
- 传染性疾病 传染性疾病
- 过敏学 过敏学
背景情况:
- 咳是2019年儿童轻型冠状病毒病 (COVID-19) 的常见症状之一.
- 关于儿童COVID-19相关咳的持续时间和严重程度的数据有限.
- 过敏疾病对这些咳症状的影响尚不清楚.
研究的目的:
- 调查咳严重程度和持续时间与COVID-19后患有过敏性疾病的儿童的整体疾病持续时间之间的相关性.
- 为了确定影响儿童群体COVID-19后长期或严重咳感染的因素.
- 评估过敏状况在轻度COVID-19后咳的持续性和强度中的特定作用.
主要方法:
- 一个单一中心的回顾性病例控制研究,涉及686名0-16岁的儿童.
- 问卷调查收集了COVID-19感染后8周的每周咳得分.
- 卡普兰-梅尔和日志等级测试分析了咳持续时间的差异;逐步回归评估了影响因素.
主要成果:
- 患有过敏疾病的儿童在COVID-19后的咳持续时间明显长,与没有过敏疾病的儿童相比 (日志排名测试,P=.002).
- 患有多种过敏症与超过4周的咳有着强烈的联系 (P<.001).
- 过敏性疾病成为与8周咳持续时间和咳严重程度增加 (P<.001) 相关的主要因素.
结论:
- 过敏性疾病在儿童从轻度COVID-19中恢复后显著导致长期和更严重的咳症状.
- 过敏状况的存在和数量是儿科患者COVID-19后咳特征的关键决定因素.
- 医疗保健提供者在COVID-19后治疗儿童持续咳时应考虑潜在的过敏状况.
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