富含巴西林提取物和劳森甲基以太对感染引起的细菌的联合作用
Nilesh Nirmal1, Pankaj Koirala1, Anandu Chandra Khanashyam2
1Institute of Nutrition, Mahidol University, 999 Phutthamonthon 4 Road, Salaya, Nakhon Pathom, 73170, Thailand.
Saudi journal of biological sciences
|April 22, 2024
概括
自然植物提取物为抗生素耐药性提供解决方案. 富含巴西林提取物 (BRE) 和法律体甲基以太 (LME) 的组合显示出对常见病原体具有显著的抗菌活性,这使得它们对食品和制药应用具有前景.
科学领域:
- 微生物学 微生物学
- 自然产品化学 自然产品化学
- 食品科学 食品科学 食品科学
背景情况:
- 细菌污染对食品,制药和生物医学行业构成风险.
- 对合成抗生素的抗菌素耐药性不断增加,需要替代解决方案.
- 自然植物提取物 (NPE) 显示出作为有效的抗菌剂的潜力.
研究的目的:
- 评估富含巴西林提取物 (BRE) 和劳索姆甲基乙烯 (LME) 的联合抗菌疗效.
- 评估BRE和LME对常见病原性细菌的协同作用.
- 探索组合NPE作为合成抗生素替代品的潜力.
主要方法:
- 确定BRE和LME单独的最小抑制度 (MIC) 和最小杀菌度 (MBC).
- 评估不同度 (2:1和1:1) 的联合BRE和LME的协同效应.
- 进行消耗时间的动力测试,以量化随着时间的推移细菌的减少.
主要成果:
- BRE显示出对格兰氏阴性细菌 (例如,沙门氏菌,P. aeruginosa) 的活性更高.
- 在LME的研究中,它被证明对阳性细菌 (如B. subtilis,S. aureus) 有效.
- BRE和LME的组合显著降低了MIC值 (P <0.05) 并在120分钟内实现了实质性的细菌日志减少.
结论:
- 结合的BRE和LME表现出广泛的抗菌活性.
- BRE和LME的协同作用增强了抗微生物药物的有效性.
- 这种天然抗菌组合被推用于食品和制药应用,作为合成抗生素的替代品.
相关概念视频
Combined Effects of Drugs: Synergism
3.9K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.9K
Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Hand hygiene
3.2K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.2K
Defense Mechanism Against Infection
6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K
Local Anesthetics: Chemistry and Structure-Activity Relationship
4.4K
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
4.4K


