在患有症状性磁盘和抑郁症状的患者中,血清细胞因子的改变

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Joanna Bielewicz¹, Beata Daniluk², Piotr Kamieniak³

¹Department of Neurology, Medical University of Lublin, Lublin, Poland.

Frontiers in neuroscience

|April 22, 2024

概括

患有椎间盘的患者的抑郁障碍与较高水平的抗炎细胞因子,转化生长因子-β (TGF-β) 和互白素-10 (IL-10) 相关. 这些细胞因子可能在这些患者观察到的功能障碍中发挥作用.

科学领域:

免疫学免疫学免疫学
精神病学是一个精神病学.
疼痛医学医学疼痛医学

背景情况:

细胞因子在抑郁障碍 (DD) 的发展中起着至关重要的作用.
在医疗病患者中,细胞因子可以引起类似于DD的疾病行为,改变应对疾病的能量消耗.
了解DD中的细胞因子参与对于管理椎间盘 (DH) 等疾病至关重要.

研究的目的:

研究促炎性细胞因子 (IL-6,TNF-α,IL-1β) 和抗炎性细胞因子 (IL-10,TGF-β) 在抑郁障碍 (DD) 中的作用.
为了检查这些细胞因子在手术中由于磁盘 (DH) 引起疼痛的患者中的作用.

主要方法:

在70名肝炎患者中使用贝克抑郁症库存评估DD强度.
测量疼痛强度和功能障碍.
预炎性细胞因子 (TNF-α,IL-1,IL-6) 和抗炎性细胞因子 (TGF-β,IL-10) 的量化血清水平.

主要成果:

在患有中度和重度抑郁症状 (SD) 的患者中,与患有轻度抑郁症状 (MD) 或没有抑郁症状 (ND) 的患者相比,观察到TGF-β,IL-10和IL-6的血清水平升高.
在SD组中,TGF-β水平与疼痛强度有负相关性.
SD组表现出最显著的功能障碍.

结论:

表明抑郁障碍与抗炎细胞因子TGF-β和IL-10之间存在关联.
尽管SD组的功能障碍更严重,但TGF-β和IL-10的血清水平增加了,TGF-β和IL-10参与愈合.

关键词:

细胞因子细胞因子抑郁症症状抑郁症症状椎间盘的发生神经病性疼痛是一种神经性疼痛.疾病行为疾病行为.

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