针对儿童急性鼻炎的抗生素:一个元分析
Shannon J Conway1, Grace D Mueller1, Nader Shaikh1
1Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Pediatrics
|April 22, 2024
概括
与安慰剂相比,抗生素显著减少了急性鼻炎儿童的治疗失败. 然而,由于条件的有利自然过程,警的等待也可能是一个可行的选择.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 急性鼻炎是儿童抗生素处方的常见原因之一.
- 最近缺乏关于抗生素疗效与安慰剂治疗儿童鼻炎的系统评价.
研究的目的:
- 评估抗生素是否比安慰剂更有效治疗儿童急性鼻炎.
- 综合了小儿鼻炎治疗的安慰剂对照试验的证据.
主要方法:
- 随机的安慰剂受控试验的系统审查和元分析.
- 搜索了Medline和Embase数据库,截至2023年7月.
- 包括的研究重点是儿童 (<18岁) 鼻炎症状<4周.
主要成果:
- 与安慰剂相比,抗生素治疗使治疗失败率降低了41% (RR0.59).
- 在删除高风险偏差研究后,研究之间的初始异质性下降.
- 抗生素使用增加了腹的风险 (RR 1.62).
结论:
- 抗生素在减少小儿急性鼻炎治疗失败方面具有显著的益处.
- 鼻炎的有利自然史表明,没有立即抗生素的观察是潜在的替代方案.
- 证据质量受到包括的研究数量少和方法差异的限制.
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