由内生植物Alternaria alternata产生的烯衍生物
Reo Takahashi1, Shin-Nosuke Isshiki1, Mayuka Hakozaki2
1Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Japan.
Natural product research
|April 22, 2024
概括
研究人员从Alternaria alternata中分离出了新型芳香型多基基. 这些化合物,包括老素,对各种细胞系和植物表现出中度的细胞毒性和植物毒性.
科学领域:
- 自然产品化学 自然产品化学
- 菌类学 菌类学是指菌类学.
- 生物化学 生物化学
背景情况:
- 内生真菌,如Alternaria alternata,是生物活性二次代谢产物的丰富来源.
- 聚基基体 (Polyketides) 是一类多样化的自然产品,具有广泛的生物活动.
- 研究内植物的化学多样性和生物活性对于发现新的治疗剂至关重要.
研究的目的:
- 从Alternaria alternata SI-694的一种内菌株中分离和描述新型芳香型多基基.
- 评估分离化合物的细胞毒性和植物毒性活动.
主要方法:
- 使用色谱技术分离和净化化合物.
- 使用核磁共振 (NMR),红外线 (IR),紫外线 (UV) 和电子循环二极化 (ECD) 谱镜进行结构阐明.
- 使用HL-60细胞的细胞毒性和植物毒性对Lactuca sativa,Brassica campestris L.,Stellaria aquatica (L.) Scop.和Digitaria ciliaris的评估.
主要成果:
- 确定了两种新的芳香多基化物 (1和3) 和五种已知的化合物 (2,4,5,6和7).
- 阿尔素 (7) 对HL-60细胞表现出中度细胞毒性 (IC50 = 6.65μM).
- 化合物5,6和7对多种植物物种表现出植物毒性.
结论:
- Alternaria alternata SI-694产生了一系列生物活性芳香型多基基化物.
- 隔离的化合物,特别是老素,具有作为细胞毒性和植物毒性剂的潜力.
- 对这些多基基的进一步研究可能会导致新药或农业化学品的开发.
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