在体外对甲福胺对活性炭吸附的研究
Yoshinori Tomoda1, Masahiro Kobayashi1
1Laboratory of Clinical Pharmacokinetics, Research and Education Center for Clinical Pharmacy, Kitasato University School of Pharmacy, Tokyo, Japan.
Clinical toxicology (Philadelphia, Pa.)
|April 22, 2024
概括
活性炭在体外表现出metformin的低吸附能力. 这表明活性炭可能不是对甲福明过量患者的有效治疗方法.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
背景情况:
- 甲胺是治疗2型糖尿病的关键药物.
- 甲福明过量服用可能会导致代谢性化和死亡等有毒效应.
- 活性炭是一种常见的中毒治疗方法,但其在甲福林过量中使用的方法尚未被证明.
研究的目的:
- 为了研究活性炭对甲胺的体外吸附能力.
- 为了确定活性炭是否是美特福林过量治疗的可行治疗选择.
主要方法:
- 活性炭与模拟胃和肠液中的甲福明溶液混合.
- 用过后的高性能液体染色学测量了甲胺度.
- 用兰格穆尔吸附等热方程来计算最大吸附能力.
主要成果:
- 吸附能力随着pH值而变化,pH值6.8 (55.9 mg/g) 的吸附能力比pH值1.2 (10.6 mg/g) 高.
- 活性炭对美特福林的吸附通常很低,类似于其他吸附不良的物质.
- 甲福明的高水溶性和极性导致吸附不良.
结论:
- 活性炭在吸附甲福明方面表现出有限的有效性.
- 活性炭不太可能有效地治疗甲胺过量服用病例.
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