在男孩中血清里素水平升高,中部早期青春期独立于BMI
Dan Zeng1, Yanfei Chen1, Tao Xie1
1Department of Paediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Endokrynologia Polska
|April 22, 2024
概括
血清里素水平可能有助于预测正常体重男孩的中央早熟青春期 (CPP). 虽然不是一个独立的测试,但虹膜素显示出强烈的特异性来识别CPP,与BMI和青春期发育标志物相关联.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢研究研究 代谢研究
- 激素信号传递 激素信号传递
背景情况:
- 中部早熟性青春期 (CPP) 是一种常见的内分泌疾病.
- 青春期的发育受营养代谢的影响.
- 素,一个肌/素,是一个潜在的预测器的CPP在女孩.
研究的目的:
- 为了研究血清里素水平和男孩的CPP之间的关系.
- 在不同体重类别中评估虹素作为CPP的诊断标志物.
主要方法:
- 用ELISA测量了CPP和33对照组的32名男孩的血清虹膜素水平.
- 按BMI分层的群体 (超重/肥胖与正常体重).
- 进行了斯皮尔曼相关性和ROC曲线分析.
主要成果:
- 与对照组相比,正常体重的男孩患有CPP有提升的虹膜素;超重/肥胖子组没有显著差异.
- 在正常体重的男孩中,CPP的最佳伊丽素切断值:93.09 ng/mL (47.6%的灵敏度,100%的特异性).
- 素,骨年龄,骨年龄的提升和BMI之间的正相关性.
结论:
- 血清里素水平与男孩的BMI和青春期发育相关.
- 虹膜呈现出高特异性,但对CPP诊断的敏感性有限.
- 虹膜可以作为CPP的补充,而不是独立的诊断工具.
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