在意大利COVID-19的第一个波浪期间,低致病性人类冠状病毒在意大利的第一个波浪期间
Ilaria Puglia1,2, Paola Ripà3, Valentina Curini2
1PhD National Programme in One Health approaches to infectious diseases and life science research, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 27100, Italy
Veterinaria italiana
|April 22, 2024
概括
在COVID-19大流行期间,意大利检测到低致病性人类冠状病毒 (HCoV). 这项研究特征了一种HCoV-229E菌株,有助于了解HCoV流行率.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 低致病性人类冠状病毒 (HCoV) 引起轻度呼吸道疾病.
- 之前在意大利的HCoV分布研究主要集中在特定的人口统计数据上.
- 在SARS-CoV-2大流行期间,关于HCoV在一般人群中的流行情况的数据有限.
研究的目的:
- 调查意大利中部低致病性HCoV的流行情况.
- 为了描述检测到的HCoVs的遗传组成.
- 为了提供有关HCoV在最初的SARS-CoV-2波的循环的见解.
主要方法:
- 使用实时RT-PCR对916个扫描样本进行分子查.
- 阳性HCoV样本的全基因组测序.
- 在阿布鲁佐州的前两个SARS-CoV-2大流行浪潮中收集的样本的分析.
主要成果:
- 在9个样本中确定了低致病性HCoV.
- 一个HCoV-229E菌株的整个基因组序列已成功获得和特征.
- 这项研究提供了意大利HCoV传播的分子证据.
结论:
- 在SARS-CoV-2大流行期间,阿布鲁佐地区存在低致病性HCoV.
- 这些发现强调了需要对HCoV进行更广泛的监测.
- 鉴定HCoV-229E的特征有助于了解冠状病毒的多样性.
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