Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bioequivalence: Overview01:16

Bioequivalence: Overview

1.0K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
1.0K
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

710
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
710
Drug Discovery: Overview01:26

Drug Discovery: Overview

7.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.8K
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

254
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
254
Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

174
Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...
174
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

70
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
70

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

phyloPipeR: An R Package for End-to-End Phylogenetic Reconstruction and Tree Comparison.

Current issues in molecular biology·2026
Same author

Radiopharmaceutical Oncology Care Supported by Ultrasound-Guided Superior Vena Cava-Right Atrial Junction Port Tip Positioning in Adult Cancer Patients.

Cancer biotherapy & radiopharmaceuticals·2026
Same author

pmultiqc: An Open-Source, Lightweight, and Metadata-Oriented QC Reporting Library for MS Proteomics.

Molecular & cellular proteomics : MCP·2026
Same author

Multi-Scale Transcriptomics Redefining the Tumor Immune Microenvironment.

Biotech (Basel (Switzerland))·2026
Same author

A multi-representation deep-learning framework for accurate multicancer classification.

Journal of translational medicine·2025
Same author

LKE-DTA: predicting drug-target binding affinity with large language model representations and knowledge graph embeddings.

Molecular diversity·2025

相关实验视频

Updated: Jun 28, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K

基于网络的异质药物重新定位方法的比较基准和评估框架.

Yinghong Li1, Yinqi Yang1, Zhuohao Tong1

  • 1Chongqing Key Laboratory of Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, Chongqing 400065, P. R. China.

Briefings in bioinformatics
|April 22, 2024
PubMed
概括

这项研究系统地对28种异质的基于网络的药物重新定位方法进行了比较. HGIMC,ITRPCA和BNNR表现出最佳表现,特定的方法在可扩展性和可用性方面表现出色.

关键词:
药物重新定位 药物重新定位评估工作流程的工作流程.不同质的网络是异质的网络.方法评价方法评价方法评价在线工具 在线工具.

更多相关视频

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
07:25

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

Published on: May 4, 2017

17.8K
Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets
06:40

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets

Published on: February 23, 2024

1.3K

相关实验视频

Last Updated: Jun 28, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.6K
In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
07:25

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

Published on: May 4, 2017

17.8K
Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets
06:40

Author Spotlight: Cost-Effective Transcriptomic Drug Screening - Unlocking New Targets

Published on: February 23, 2024

1.3K

科学领域:

  • 计算生物学是一种计算生物学.
  • 药理学 药理学是指药理学的学科.
  • 生物信息学是一种生物信息学.

背景情况:

  • 计算药物重新定位通过确定现有药物的新用途,降低成本和时间表来加速药物发现.
  • 基于异质网络的方法是有希望的,但缺乏对性能,可扩展性和可用性的系统评估.
  • 现有的比较研究是有限的,并产生相互矛盾的结果.

研究的目的:

  • 对28种基于网络的异质药物重新定位方法进行全面,系统的基准测试.
  • 建立一个标准化的框架来评估方法性能,可扩展性和可用性.
  • 为研究人员提供可靠的数据,以选择适当的药物重新定位工具.

主要方法:

  • 在11个不同的数据集中对28种异构的基于网络的药物重新定位方法进行基准测试.
  • 开发一个全面的评估框架,评估性能,可扩展性和可用性.
  • 使用矩阵完成和因子化技术进行性能分析.

主要成果:

  • HGIMC,ITRPCA和BNNR表现出优越的整体性能,经常利用矩阵完成/因子化.
  • 亨格尔,MLMC,ITRPCA和HGIMC显示出最好的预测性能.
  • NMFDR,GROBMC和SCPMF表现出最高的可扩展性.
  • 确定HGIMC,DRHGCN和BNNR是最易于使用的方法.

结论:

  • 该研究提供了基于网络的异质药物重新定位方法的强有力的评估.
  • HGIMC,ITRPCA,BNNR,HINGRL,MLMC,NMFDR,GROBMC,SCPMF和DRHGCN因其优势而受到重视.这些公司的优势包括:
  • 开发的在线工具 (HN-DREP) 和工作流 (HN-DRES) 便于方法选择和未来的研究.