相关实验视频
Updated: Jun 28, 2025

08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.2K
患病率和与慢性病中掩盖高血压相关的因素
Frédéric Legrand1, Justina Motiejunaite2,3,4, Florence Arnoult2
1Faculté de médecine, Sorbonne Université.
Journal of hypertension
|April 22, 2024
概括
蒙面高血压,即在诊所血压正常但在家高,影响了超过一半的慢性脏病患者,他们的办公室血压受到控制. 建议进行常规的门诊血压监测 (ABPM),以更好地管理CKD中的心血管风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 高血压研究 高血压研究
背景情况:
- 优化血压控制对于预防慢性病患者心血管并发症至关重要.
- 蒙面高血压,以正常的办公室血压为特征,但在办公室外血压升高,是CKD管理中的一个重要问题.
- 了解掩盖高血压的患病率和促成因素对于改善患者的治疗结果至关重要.
研究的目的:
- 为了确定患有慢性脏病的患者面具高血压的患病率.
- 为了确定与该人口中的掩盖高血压相关的临床和人口因素.
主要方法:
- 分析了1113名接受功能评估的632名患者的24小时门诊血压监测 (ABPM) 记录.
- 掩盖高血压的定义:办公室血压<140/90 mmHg,白天血压≥135/85 mmHg或夜间血压≥120/70 mmHg.
- 混合后勤回归模型被用来评估与掩盖高血压相关的因素.
主要成果:
- 在受控办公室血压患者中 (67%的队列),56%的患者表现出掩盖的高血压.
- 与掩盖高血压相关的因素包括男性性别,撒哈拉以南非洲起源,较高的BMI和白尿.
- 观察到与血,24小时尿路分泌以及使用RAAS抑制剂和利尿剂的负面关联.
结论:
- 常规的ABPM在CKD患者中得到支持,因为即使在控制的办公室BP中,掩盖高血压也非常普遍.
- 诸如体重管理,监测和补充 (谨慎) 等策略,以及增加RAAS阻断剂和利尿剂的使用,可以改善室外血压控制.
- 这些发现强调了除了办公室内测量之外,全面的BP监测对于有效的CKD管理的重要性.
相关概念视频
Hypertension and Regulation of Blood Pressure
2.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
Factors Affecting Renal Clearance: Renal Impairment
91
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
91
Factors affecting Blood pressure
3.2K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
3.2K
Antihypertensive Drugs: Potassium-Sparing Diuretics
531
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
531
Antihypertensive Drugs: Direct Renin Inhibitors
613
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
613
Alterations in Blood Pressure
1.2K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.2K

