在老年和非老年患者之间比较胃肠道 stromal 瘤结果:基于人口的分析
Abhiram Singh1,2, Bhargava Chitti1, Christopher Aguiar3
1Department of Radiation Oncology, Northwell, New Hyde Park, New York, USA.
World journal of surgery
|April 22, 2024
概括
胃肠道筋瘤 (GISTs) 的生存率有所改善,但老年患者 (≥70岁) 面临的结果明显较低. 手术对所有GIST患者都有好处,这强调了它在治疗中的重要性,无论年龄如何.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 癌症流行病学 癌症流行病学
背景情况:
- 胃肠道筋瘤 (GISTs) 是胃肠道中最常见的介质细胞瘤.
- 基于人口的癌症登记,如SEER,对于分析GIST发病率和结果的趋势至关重要.
- 本研究专门研究基于年龄的GIST患者的生存差异,比较老年 (≥70岁) 和非老年人群.
研究的目的:
- 研究和比较被诊断患有胃肠道筋瘤 (GIST) 的老年与非老年患者的生存结果.
- 分析手术干预对不同年龄组GIST存活率的影响.
- 确定影响老年人群GIST结果的人口和治疗相关因素.
主要方法:
- 利用SEER数据库 (2000-2019) 来提取13,579名GIST患者的数据.
- 定义老年患者为70岁或以上的个人.
- 使用Kaplan-Meier生存估计,Log-Rank测试和多变量Cox比例危险回归来分析生存和危险比率.
主要成果:
- 在GIST患者中,整体5年生存率为68.6%. 从2000年到2019年,癌症特定死亡率大幅下降.
- 老年患者的5年生存率 (53.3%) 与非老年患者 (77.4%) 相比显著降低 (p < 0.0001).
- 手术显著改善了年轻 (83.7%) 和老年 (62.8%) 患者的5年生存率,与没有接受手术的患者相比 (分别为48.7%和29.3%) (p < 0.0001). 老年患者的死亡风险增加了2.56倍.
结论:
- GIST的生存率有所改善,但老年患者的治疗结果较差.
- 手术干预是改善所有年龄段GIST存活率的关键因素.
- 需要进一步的前性研究来优化老年GIST患者的临床管理策略.
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