吸烟强度与视神经头血管密度的渐进性损失有关,而在玻璃眼中
Takashi Nishida1, Robert N Weinreb1, Natchada Tansuebchueasai1,2
1Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, CA.
Journal of glaucoma
|April 22, 2024
概括
更大的吸烟消费加快了视神经头毛细血管密度的损失在青光眼患者. 吸烟强度是青光眼的进展和管理的一个关键因素.
科学领域:
- 眼科医生 眼科 眼科
- 新血管化研究研究
- 眼研究研究研究眼
背景情况:
- 玻璃眼是导致不可逆转失明的主要原因.
- 视神经头部 (ONH) 微血管结构的变化是绿眼瘤进展的指标.
- 吸烟是一个普遍存在的风险因素,具有潜在的眼睛影响.
研究的目的:
- 检查吸烟强度与视神经头部全图像毛细血管密度 (wiCD) 损失的速度之间的关联.
- 为了在患有初级开角青光眼 (POAG) 和怀疑青光眼的患者中研究这种关系.
主要方法:
- 纵向研究分析了POAG和可疑青光瘤患者的光学连贯性断层扫描血管学 (OCTA) 数据.
- 在基线使用包装年量化吸烟强度.
- 线性混合效应模型和断片回归分析了wiCD损失率并确定了切断点.
主要成果:
- 在研究的110名患者中,45.5%的人报告吸烟史.
- 增加的吸烟强度 (每10包年) 与更快的wiCD损失率相关 (-0.11%/年).
- 在吸烟强度超过22.2包年的人群中观察到显著加速的wiCD稀释.
结论:
- 较高的终身吸烟消费与视神经头部加速的血管密度损失有关.
- 吸烟强度成为影响绿眼病进展的重要危险因素.
- 对青光眼的临床评估应纳入吸烟史,以进行风险分层和管理策略.
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