在危急疾病期间发生全身炎症和妄想
Nathan E Brummel1,2,3, Christopher G Hughes3,4,5, J Brennan McNeil3,6
1Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University College of Medicine, Columbus, OH, USA.
炎症标志物和蛋白C水平与重症患者的妄想和昏迷有关. 这些发现突出了重症监护病房中精神状态变化的潜在生物标志物.
科学领域:
- 关键护理医学 关键护理医学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 妄想和昏迷是重症患者常见的并发症.
- 了解潜在的病理生理学对于及时干预至关重要.
研究的目的:
- 调查炎症标志物和内源性抗凝剂活性与危重病患者妄和昏迷之间的关联.
主要方法:
- 对991名在重症监护病房 (ICU) 的成年人进行前性队列研究.
- 使用RASS和CAM-ICU评估精神状态.
- 测量了各种炎症标志物 (CRP,IFN-γ,IL-1β,IL-6,IL-8,IL-10,IL-12,MMP-9,TNF-α,TNFR1) 和蛋白C的血液水平.
- 使用后勤回归来分析与妄想或昏迷的关联.
主要成果:
- 较高的IL-6,IL-8,IL-10,TNF-α和TNFR1水平与妄想有关.
- 较低的C蛋白水平与妄和昏迷有关.
- 较高的CRP和IFN-γ水平与昏迷有关.
- IL-1β,IL-12和MMP-9与精神状态没有显著的关联.
结论:
- 炎症标志物和内源性抗凝剂活性与危急疾病中的妄想和昏迷有关.
- 这些生物标志物可能在ICU中改变精神状态的发展中发挥作用.
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