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Updated: Jun 28, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
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Published on: February 15, 2016

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设计一种诺科克劳林合成酶,用于单步合成 (S) -1-aryl-tetrahydroisoquinolines

Man Zhang1, Zheng-Yu Huang1, Ying Su1

  • 1State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, College of Biotechnology, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.

Bioresources and bioprocessing
|April 22, 2024
PubMed
概括

研究人员设计了一种突变的诺科克劳林合成酶 (NCS) 酶,以有效地合成有价值的1-aryl-tetrahydroisoquinoline类化合物 (THIQAs). 这种改进的酶在制药应用中表现出高活性和立体选择性.

关键词:
生物催化剂是一种生物催化剂.诺科克劳林合成酶的使用皮克特斯潘格勒反应蛋白质工程是一种蛋白质工程.甲基化素化素化物

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