长期的第二代抗精神病药物降低了精神分裂症男性患者的骨形成和再吸收
Fan Wang1,2,3, Hui Li4, Kaijun Yi5
1Beijing Hui-Long-Guan Hospital, Peking University, Beijing, 100096, China. FanWang@bjmu.edu.cn.
Psychopharmacology
|April 22, 2024
概括
精神分裂症患者的第二代抗精神病药物 (SGA) 治疗抑制了骨的形成和再吸收,破坏了骨代谢平衡. 这项研究研究了骨循环生物标志物 (PINP和CTX-1),以了解SGA对骨脆弱性的影响.
科学领域:
- 生物医学科学 生物医学科学
- 药理学 药理学是指药理学的学科.
- 代谢性骨疾病 代谢性骨疾病
背景情况:
- 第二代抗精神病药物 (SGA) 与精神分裂症患者的骨脆弱性和骨折风险增加有关.
- SGAs对骨代谢平衡的确切影响尚不清楚.
研究的目的:
- 在接受SGA治疗的精神分裂症患者中,研究骨循环生物标志物 (BTM) 的变化,包括前原I型aminoterminal propeptide (PINP) 和I型原C终端端端 (CTX-1).
- 通过检查它们对骨质生成和骨再吸收的影响,探索SGA如何促进骨脆弱性.
主要方法:
- 招募59名中国男性精神分裂症患者 (32名先前未服用过药物,27名慢性).
- 用SGA治疗8周,在治疗前和治疗后采集的血液样本.
- 测量PINP和CTX-1的血水平,以评估骨形成和再吸收标记.
主要成果:
- 观察到对PINP和CTX-1度的群体和时间的显著相互作用影响 (P=.016和P=.008).
- 与治疗前相比,两种BTM在治疗后显著下降 (P<.001和P=.003).
- 慢性患者在BTM的变化显著更大,相比之前没有服用过药物的第一期患者 (P=.048和P=.024).
结论:
- 长期的SGA药物以剂量和时间依赖的方式抑制骨质生成.
- SGA 破坏了骨形成和骨再吸收之间的平衡,导致骨脆弱.
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