Aureobasidium pullulans lysate 对受紫外线损伤的人类皮肤纤维细胞和 HaCaT 细胞的保护作用
Xin Wang1,2, Yongtao Zhang1,2, Dongdong Wang1,2
1Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, People's Republic of China.
Bioresources and bioprocessing
|April 22, 2024
概括
奥雷奥巴西普卢兰斯溶解酸通过减少炎症和氧化应激,保护皮肤细胞免受紫外线损伤. 这种天然化合物显示出抗光衰老和保持皮肤健康的潜力.
科学领域:
- 生物技术是生物技术.
- 皮肤病学 皮肤病学
- 化品科学 化品科学
背景情况:
- 乌雷奥巴西普鲁兰斯 (A. pullulans) 具有多样化的应用.
- 紫外线 (UV) 辐射诱导皮肤的光衰老.
- 研究A. pullulans lysate对紫外线损伤的皮肤细胞的保护作用至关重要.
研究的目的:
- 为了评估A. pullulans lysate的抗衰老和抗炎性质.
- 为了阐明A. pullulans lysate的抗氧化应激机制.
- 评估A. pullulans溶解酸对受紫外线损伤的人类皮肤纤维细胞 (HSF) 和HaCaT细胞的影响.
主要方法:
- 进行了细胞毒性测试.
- 使用了与酶相关的免疫吸收试验 (ELISA).
- 实时定量PCR (RT-qPCR) 用于基因表达分析.
主要成果:
- A. pullulans lysate减少了细胞外矩阵组件的损失 (原,氨酸).
- 它清理了活性氧物种 (ROS),增强了催化酶活性,并降低了矩阵金属蛋白酶 (MMP).
- 组织金属蛋白酶抑制剂 (TIMPs) 的基因表达得到增强,炎症因素减少,HaCaT细胞中的紫外线诱导的亡减少,通过Nrf2/Keap1和MAPK通路调节氧化应激.
结论:
- A. pullulans lysate在打击光衰老方面表现出显著的潜力.
- 这项研究强调了其在保护皮肤细胞免受紫外线引起的损伤方面的有效性.
- A. pullulans lysate可以作为抗衰老护肤配方中的一个有价值的成分.
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