缓解抗菌素耐药性,一种管理犬类尿路感染的方法
M A Ensha Lomiya1, R Raguvaran2, Debabrata Mondal1
1Division of Medicine, Indian council of Agricultural Research- Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
Veterinary research communications
|April 22, 2024
概括
狗尿路感染 (UTI) 的抗菌素耐药性是一个越来越令人担忧的问题. 与一般指导方针相比,局部抗生素计数据显著提高了治疗成功率,强调了在兽医中需要量身定制的抗生素选择.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 狗尿路感染中的抗菌素耐药性 (AMR) 对动物和人类健康构成重大风险.
- 了解流行尿病原体及其药物易感性对于有效的抗菌药物管理至关重要.
- 目前的国际实证治疗指南可能对当地犬类尿路感染病例来说不是最佳的.
研究的目的:
- 为了识别导致狗尿路感染的常见细菌尿病原体.
- 为了确定这些分离物的抗微生物敏感性模式 (抗生素).
- 为了比较实证疗法的疗效与对犬类尿路感染的敏感性导向治疗.
主要方法:
- 从35只具有尿路感染临床症状的狗身上收集了尿液样本.
- 鉴定了细菌分离物,并测试了它们对抗生素的敏感性.
- 一组无并发性尿路感染的狗被用实证疗法 (阿莫西西林 - 克拉夫兰酸) 或灵敏性导向疗法 (基普罗夫洛克萨或基尼托福兰治疗方案) 治疗.
主要成果:
- 大肠杆菌是最常见的分离物,其次是Klebsiella aerogenes,金黄色葡萄球菌,Proteus mirabilis,Enterococcus sp.和Citrobacter freundii.这些分离物是最常见的.
- 所有分离物体都对至少一种一线抗生素表现出耐药性,70%的分离物体表现出多药耐药性.
- 治疗成功率在接受抗生素以敏感性测试为指导的组 (基普洛克萨和尼托福兰组) 与经验性阿莫西西林 - 克拉夫兰酸治疗相比较高.
结论:
- 局部抗生素检查数据对于指导有效的抗生素选择在犬类尿路感染中至关重要.
- 根据敏感性指导的治疗,与基于国际指导方针的经验性治疗相比,显示出更好的结果.
- 在兽医实践中实施本地抗菌素检查数据可以帮助对抗伴侣动物的抗菌素耐药性.
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