在老年人中感知压力,血液生物标志物和认知功能
Pankaja Desai1, Ted K S Ng, Kristin R Krueger
1From the Rush Institute for Healthy Aging (Desai, Ng, Krueger, Evans, Rajan) and Rush Alzheimer's Disease Center (Wilson), Rush University Medical Center, Chicago, Illinois; and Department of Neurology, University of California at Davis (Rajan), Davis, California.
Psychosomatic medicine
|April 22, 2024
概括
高压力加剧了神经纤维光链 (NfL) 水平升高和老年人认知能力下降之间的联系. 压力管理可能会减缓高NfL的人的认知衰退.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 阿尔茨海默氏症疾病的生物标志物
背景情况:
- 关于感知压力对血清阿尔茨海默病生物标志物与认知衰退之间的关系的影响,存在重大知识差距.
- 了解这种相互作用对于开发针对老年人群认知健康的有针对性的干预措施至关重要.
研究的目的:
- 调查感知压力在特定血液生物标志物 (总,GFAP,NfL) 与老年人全球认知衰退之间的关联中的作用.
- 评估压力水平如何随着时间的推移改变这些生物标志物和认知功能之间的关系.
主要方法:
- 在芝加哥健康与衰老项目 (CHAP) 中,分析了1118名老年人的数据.
- 使用线性混合效应回归模型来评估感知压力,NfL度和认知衰退时间之间的相互作用.
- 模型根据人口和时间因素进行调整,并根据压力水平进行分层分析.
主要成果:
- 在压力,神经纤维光链 (NfL) 度和全球认知时间 (β = -0.064,p = .023) 之间发现了统计学上显著的相互作用.
- 这种相互作用也对情节性记忆具有重要意义 (β = -0.097,p = .007).
- 较高的压力水平与NfL对认知能力下降的较大负面影响有关.
结论:
- 增加感知压力会放大高NfL度对认知衰退的有害影响.
- 压力管理干预措施显示出减轻高NfL水平的个体认知衰退率的潜力.
- 这凸显了在阿尔茨海默病研究中考虑心理因素与生物标志物的重要性.
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