在冠状动脉疾病中对心理压力和认知功能的血液动力学反应性
Kasra Moazzami1, Ambar Kulshreshtha, Matthew Gold
1From the Division of Cardiology, Department of Medicine (Moazzami, Gold, Rahbar, Quyyumi), Emory Clinical Cardiovascular Research Institute; Grady Health System (Moazzami); Department of Epidemiology, Rollins School of Public Health (Kulshreshtha, Shah, Vaccarino), Emory University; Departments of Family and Preventive Medicine (Kulshreshtha) and Neurology (Goldstein), and Goizuetta Alzheimer's Disease Research Center (Goldstein), Emory University School of Medicine, Emory University, Atlanta; Atlanta VA Medical Center (Shah, Bremner), Decatur; Departments of Radiology and Imaging Sciences (Bremner) and Psychiatry and Behavioral Sciences (Bremner), Emory University School of Medicine, Atlanta, Georgia.
在患有冠状动脉疾病 (CAD) 的人中,对精神压力的血动力学反应减弱与认知功能较差以及执行功能和视觉运动处理随着时间的推移的更快下降有关.
科学领域:
- 心脏病学 心脏病学
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
背景情况:
- 冠状动脉疾病 (CAD) 患者面临认知障碍的风险较高.
- 心理压力是CAD和认知衰退的已知危险因素.
- 研究对心理压力的血液动力反应性可能会阐明压力与认知健康之间的联系.
研究的目的:
- 为了检查血液动力学对急性精神压力的反应和稳定的CAD患者的认知功能之间的联系.
- 为了确定这种关联是否会在2年的随访期内预测认知能力下降.
主要方法:
- 两项前性队列研究包括779名患有稳定的CAD的个人.
- 参与者在基线和2年后进行了急性心理压力测试和认知功能评估.
- 速度-压力产品 (RPP) 反应率被计算为心理压力测试期间RPP的变化.
主要成果:
- 对心理压力的RPP反应性下降显著与在基线时在Trail-A和Trail-B上的表现减缓有关.
- 这种模糊的血液动力学反应也预测了视觉运动处理和执行功能在2年内更大的下降.
- 在常规压力测试和认知表现期间的RPP反应性之间没有发现显著的关联.
结论:
- 在患有CAD的患者中,对精神压力的血液动力反应减弱与视觉运动处理和执行功能受损有关.
- 这种模糊的反应预示着这些认知能力随着时间的推移而恶化.
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