阻塞性睡眠呼吸暂停的严重程度,循环生物标志物和癌症风险
A J Hirsch Allen1, Tetyana Kendzerska2, Parveen Bhatti3,4
1Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
概括
阻塞性睡眠呼吸暂停 (OSA) 的严重程度是癌症的独立风险因素. 特定的炎症和血管新生生物标志物也显示了与OSA患者癌症风险增加的关联.
科学领域:
- 睡眠医学 睡眠医学
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的睡眠障碍.
- 炎症和血管生成在癌症的发展中起作用.
- 需要进一步调查OSA严重程度,生物标志物和癌症风险之间的联系.
研究的目的:
- 调查OSA严重程度与发生癌症之间的关联.
- 探索炎症/血管新生生物标志物与OSA患者癌症风险之间的关系.
主要方法:
- 研究了一组1,990名接受过多睡眠扫描的成年患者.
- 收集了关于OSA严重程度,炎症和血管生成生物标志物的数据.
- 考克斯比例危险回归分析了从癌症注册表中与事件癌症诊断的关联.
主要成果:
- OSA的严重程度与癌症风险增加显著相关 (HR=1.08每10个AHI增加,P=.015).
- 两个生物标志物,内静止素 (HR=1.45) 和VCAM-1 (HR=1.48),与更高的癌症风险有关.
- 在平均12.8年的随访期间,共有181名患者 (9.1%) 患上癌症.
结论:
- OSA的严重程度是癌症发展的独立风险因素.
- 循环生物标志物如内静止素和VCAM-1可能表明OSA患者的癌症风险增加.
- 需要进一步的研究来验证这些发现,并探索生物标志物对OSA癌症风险预后的实用性.
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