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呼出的挥发性有机化合物用于中度至重度喘儿童的喘控制分类:SysPharmPediA研究的结果
Shahriyar Shahbazi Khamas1,2,3,4, Yoni Van Dijk1,2,3,4, Mahmoud I Abdel-Aziz1,2,3,4
1Department of Pulmonary Medicine and.
American journal of respiratory and critical care medicine
|April 22, 2024
概括
分析排出的挥发性有机化合物 (VOC) 可以帮助识别患有失控喘的儿童. 这种方法对开发用于儿童喘管理的新诊断工具充满希望.
科学领域:
- 生物化学 生物化学
- 儿科肺病学 儿科肺病学
- 分析化学 分析化学
背景情况:
- 早期识别儿童控制不良的喘对于有效治疗至关重要.
- 呼出的挥发性有机化合物 (VOC) 是用于识别儿科喘中的生物标志物的新兴领域.
研究的目的:
- 评估基于气色谱-质谱的呼气代谢物分析在区分受控和不受控制的儿科喘中的准确性.
- 评估VOCs在预测儿童未来严重喘发作方面的潜力.
主要方法:
- 在呼出的VOC分析中使用发现 (SysPharmPediA) 和验证 (U-BIOPRED,PANDA) 阶段.
- 在独立的儿科喘队列中确定了有区别的VOC和验证的发现.
- 基于测试分数和严重发作史的分类喘控制;评估VOCs用于预测未来的发作.
主要成果:
- 在发现阶段,三种VOC (乙,乙,) 在受控和不受控制的喘之间进行了区分.
- 在接受器下实现的区域运行特征曲线 (AUROCC) 为0.83 (训练) 和0.77 (测试) 以区分喘控制.
- 经验证的VOC组合显示AUROCC为0.74 (U-BIOPRED) 和0.68 (PANDA);攻击预测在训练和测试组合中都产生了0.71的AUROCC.
结论:
- 呼出代谢物分析显示了在儿科患者中对喘控制进行分类的潜力.
- 这种方法可以推动发展用于喘管理的临床检测.
- 对呼出的VOC进行进一步的研究可能会导致改善儿童喘的诊断和预后工具.
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